Establishment of an Acanthamoeba keratitis mouse model confirmed by amoebic DNA amplification
نویسندگان
چکیده
منابع مشابه
Successful treatment of Acanthamoeba keratitis without anti-amoebic agents.
Dear Editor, Acanthamoeba species are opportunistic pathogens that can cause life-threatening diseases in the immunocompromised host. In healthy individuals, Acanthamoeba can cause ulcerating keratitis, which is associated with the use of improperly sterilised contact lenses, trauma or washing with contaminated water.1 Reports have shown that the defenses of a healthy host seemed sufficient to ...
متن کامل[Acanthamoeba keratitis].
Three patients, women aged 69, 25 and 30 years, with refractory keratitis were found to have a rare infection with Acanthamoeba. All wore soft contact lenses. The frequency of Acanthamoeba keratitis increased in recent years. At present, an efficacious antiprotozoal therapy is available, for instance in the form of polyhexamethylene biguanide and propamidine. In cases of refractory keratitis, t...
متن کاملPersistence of acanthamoeba antigen following acanthamoeba keratitis.
AIM To investigate the hypothesis that persistent corneal and scleral inflammation following acanthamoeba keratitis is not always caused by active amoebic infection but can be due to persisting acanthamoebic antigens METHODS 24 lamellar corneal biopsy and penetrating keratoplasty specimens were obtained from 14 consecutive patients at various stages of their disease and divided for microscopy...
متن کاملOral immunization with Acanthamoeba castellanii mannose-binding protein ameliorates amoebic keratitis.
Acanthamoeba castellanii mannose-binding protein (MBP) mediates adhesion of the amoebae to corneal epithelial cells, a key first step in the pathogenesis of Acanthamoeba keratitis (AK), a devastating corneal infection. In the present study, we demonstrate that oral immunization with recombinant MBP ameliorates AK in a hamster animal model and that this protection is associated with the presence...
متن کاملGenotyping of Acanthamoeba Species Isolated from Keratitis Patients by PCR Sequencing Methods in Tehran, Iran
Background and Aims: Amoebae of the genus Acanthamoeba are unicellular amphizoic opportunistic pathogens that may cause fatal granulomatous encephalitis, eye keratitis, amebic pneumonitis and skin nodules as well as abscesses in humans and animals. Acanthamoeba keratitis is caused by trauma to the eye, contaminated cleaning solutions and the use of contact lenses. The aim of the present study w...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-83738-4